Retroviral vector targeting to human immunodeficiency virus type 1-infected cells by receptor pseudotyping |
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| Authors: | Somia N V Miyoshi H Schmitt M J Verma I M |
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| Affiliation: | Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. |
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| Abstract: | We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression. |
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