Studies of the regulation of rabbit muscle phosphofructokinase by the adenine nucleotides. |
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| Authors: | D Mangnall C Nesbitt |
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| Affiliation: | 1. Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran;2. Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran;3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Razi Herbal Medicine Research Center, Lorestan University of Medical Science, Khorramabad, Iran;5. Babol University of Medical Sciences, Babol, Iran;6. Student of Research Committee, Lorestan University of Medical Sciences, Khoramabad, Iran;1. Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 500019 Brasov, Romania;2. Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain;3. Faculty of Electrical Engineering and Computer Sciences, Transilvania University of Brasov, Bdul Eroilor 29, 500039 Brasov, Romania;4. Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, Bulevardul Eroii Sanitari, nr. 8, sector 5, Bucharest, Romania;1. National Research Institute of Fisheries Science, Japan Fisheries Research and Education Agency, Yokohama 236-8648, Japan;2. Faculty of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan;3. Cawthron Institute, Nelson 7010, New Zealand;1. Graduate Program in Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, Santa Catarina (SC), Brazil;2. Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, Santa Catarina (SC), Brazil;3. Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, USA;4. Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina (UEL), Londrina, Paraná (PR), Brazil;5. Department of Preventive Veterinary Medicine, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul (RS), Brazil;6. Laboratory of Pathology, Instituto Federal Catarinense (IFC), Concórdia, Santa Catarina (SC), Brazil;1. School of Science and Engineering, Navrachana University, Vadodara, Gujarat, India;2. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia |
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| Abstract: | - 1.1. The effects of ATP, ADP and AMP on the activity of rabbit muscle phosphofructokinase have been investigated with the nucleotides present singly or in combination.
- 2.2. The effects of the nucleotides are not additive and the response to a mixture cannot be readily deduced from the effects due to each in isolation.
- 3.3. The response to the adenylate energy charge ratio is independent of the total concentration of adenine nucleotides at pH 7.0, but at higher pHs the shape of the response curve is changed, and the activity at any given energy charge value increases with decreasing adenine nucleotide pool size.
- 4.4. If such effects operate in vivo, it is suggested that increases in gluconeogenic flux are associated with an increased rate of substrate cycling at the level of phosphofructokinase and fructose 1,6-diphosphatase.
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