Bim and Bcl-2 mutually affect the expression of the other in T cells |
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Authors: | Jorgensen Trine N McKee Amy Wang Michael Kushnir Ella White Janice Refaeli Yosef Kappler John W Marrack Philippa |
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Affiliation: | Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. |
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Abstract: | The life and death of T cells is controlled to a large extent by the relative amounts of Bcl-2-related proteins they contain. The antiapoptotic protein Bcl-2 and the proapoptotic protein Bim are particularly important in this process with the amount of Bcl-2 per cell dropping by about one-half when T cells prepare to die. In this study we show that Bcl-2 and Bim each control the expression of the other. Absence of Bim leads to a drop in the amount of intracellular Bcl-2 protein, while having no effect on the amounts of mRNA for Bcl-2. Conversely, high amounts of Bcl-2 per cell allow high amounts of Bim, although in this case the effect involves increases in Bim mRNA. These mutual effects occur even if Bcl-2 is induced acutely. Thus these two proteins control the expression of the other, at either the protein or mRNA level. |
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