Gastroretentive drug delivery system of carbamazepine: Formulation optimization using simplex lattice design: A technical note |
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| Authors: | Dasharath M. Patel Natvarlal M. Patel Nitesh N. Pandya Pranav D. Jogani |
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| Affiliation: | (1) Department of Pharmaceutics, Shri B. M. Shah College of Pharmaceutical Education & Research, 383 315 Modasa, India;(2) Zydus Cadila Healthcare Ltd, Ahmedabad, India |
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| Abstract: | Summary and Conclusion An attempt was made to develop a gastroretentive drug delivery system of carbamazepine using HPMC, sodium bicarbonate, and EC as matrixing agent, gas-generating agent, and floating enhancer, respectively. A simplex lattice design was applied to investigate the combined effect of 3 formulation variables (ie, amount of HPMC (X 1), EC (X 2), and sodium bicarbonate (X 3). Results of multiple regression analysis indicated that low levels ofX 1 andX 2 and a high level ofX 3 should be used to manufacture the tablet formulation with desired in vitro floating time and dissolution. Formulation S3 was selected as a promising formulation and was found stable at 40°C temperature and 75% RH for 3 months. Published: February 9, 2007 |
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| Keywords: | Gastroretentive carbamazepine simplex lattice design melt-granulation floating |
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