Gastroretentive drug delivery system of carbamazepine: Formulation optimization using simplex lattice design: A technical note |
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| Authors: | Dasharath M Patel Natvarlal M Patel Nitesh N Pandya Pranav D Jogani |
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| Institution: | (1) Department of Pharmaceutics, Shri B. M. Shah College of Pharmaceutical Education & Research, 383 315 Modasa, India;(2) Zydus Cadila Healthcare Ltd, Ahmedabad, India |
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| Abstract: | Summary and Conclusion An attempt was made to develop a gastroretentive drug delivery system of carbamazepine using HPMC, sodium bicarbonate, and
EC as matrixing agent, gas-generating agent, and floating enhancer, respectively. A simplex lattice design was applied to
investigate the combined effect of 3 formulation variables (ie, amount of HPMC (X
1), EC (X
2), and sodium bicarbonate (X
3). Results of multiple regression analysis indicated that low levels ofX
1 andX
2 and a high level ofX
3 should be used to manufacture the tablet formulation with desired in vitro floating time and dissolution. Formulation S3
was selected as a promising formulation and was found stable at 40°C temperature and 75% RH for 3 months.
Published: February 9, 2007 |
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| Keywords: | Gastroretentive carbamazepine simplex lattice design melt-granulation floating |
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