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Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta) |
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| Authors: | Huimin Qi Liye HuangXiaolei Liu Dongmei LiuQuanbin Zhang Shunmei Liu |
| Affiliation: | a Weifang Medical University, No. 7166 Baotong Road, Weifang 261053, PR China b Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China c Shandong Institute of Scientific and Technical Information, Jinan 250101, PR China d Weifang University, No. 5147 Dongfeng Road, Weifang 261061, PR China |
| Abstract: | In this study, high sulfate content ulvan (HU) was prepared with sulfur trioxide/N,N-dimethylformamide (SO3-DMF) in formamide, and the antihyperlipidemic activity of ulvan and HU in mice was determined. Obvious differences in antihyperlipidemic activity between natural ulvan and HU were observed, moreover, the antihyperlipidemic activity of HU-fed 250 mg/kg was the strongest, compared to natural ulvan fed group, triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) concentrations were significantly decreased 28.1% (P < 0.05) and 28.4% (P < 0.01), respectively. It was likely that the sulfate content had significant effect on the antihyperlipidemic activity. On the other hand, the results proved that the antihyperlipidemic activity was not concentration dependent for HU-fed mice. |
| Keywords: | U, ulvan HU, high sulfate content ulvan SO3-DMF, sulfur trioxide/N,N-dimethylformamide TC, total cholesterol TG, triglyceride HDL-C, high density lipoprotein cholesterol LDL-C, low density lipoprotein cholesterol |
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