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Immunoregulatory effects of a glucogalactan from the root of Panax quinquefolium L. |
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| Authors: | Wenjing ZhuBo Han Yun SunZhenyu Wang Xiuhua Yang |
| Institution: | a The Abdominal Ultrasound Department, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China b The Oncology Department, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China c The Respiratory Department, Third Affiliated Hospital of Peking University, Beijing 100191, China d School of Public Health, Shenyang Medical College, Shenyang 110034, China |
| Abstract: | In this research we purified one homogeneous glucogalactan from the roots of Panax quinquefolium, with a molecular weight of 54 kDa estimated by high-performance gel permeation chromatography (HPGPC). The monosaccharide composition of PPQ was composed of Glc (glucose) and Gal (galactose) in a molar ratio of 2.1:1, as determined by gas chromatography (GC). In order to evaluate the anti-lung carcinoma and immunoregulatory effects of this glucogalactan in mice, we established a Lewis lung carcinoma model in C57BL/6 mouse. The results showed that PPQ not only could inhibit the growth of lung tumor, but also enhance the thymus and spleen indices, as well as the level of IFN-γ, IL-10 and IL-2, indicating PPQ could have a possible cancer therapeutic potential. |
| Keywords: | Panax quinquefolium Glucogalactan Anti-Lewis lung carcinoma Immunoregulatory effects |
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