Cytotoxic palladium(II) complexes of 8-aminoquinoline derivatives and the interaction with human serum albumin |
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Authors: | Yan Liangliang Wang Xiaoyong Wang Yanqing Zhang Yangmiao Li Yizhi Guo Zijian |
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Institution: | a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR Chinab State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210093, PR Chinac Institute of Applied Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng, 224002, PR China |
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Abstract: | Palladium(II) complexes are potential antitumor metallodrugs for their chemical resemblance to platinum(II) complexes. Two palladium(II) complexes (1 and 2) in the formula of PdLnCl] L1 = N-(tert-butoxycarbonyl)-l-methionine-N′-8-quinolylamide, L2 = L-alanine-N′-8-quinolylamide] have been synthesized accordingly. The structures of the complexes were fully characterized by X-ray crystallography. The palladium(II) center in 1 is coordinated by two N atoms and an S atom from L1 with one chloride anion as the leaving group; while that in 2 is coordinated by three N atoms from L2 with one chloride anion as the leaving group. The interaction between complex 1 and human serum albumin (HSA) has been investigated using fluorescence and circular dichroism spectroscopies. The complex seems to react with HSA chiefly through hydrophobic and electrostatic interactions, and it does not alter the α-helical nature of HSA. The cytotoxicity of these complexes has been tested against the human cervical cancer (HeLa), human mammary cancer (MCF-7), and human lung cancer (A-549) cell lines. Complex 1 displays a cytotoxic activity comparable to that of cisplatin, but complex 2 is less active than cisplatin. |
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Keywords: | Palladium(II) complex Crystal structure Antitumor activity Human serum albumin |
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