Physiological aspects on catecholamine sampling |
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| Authors: | P Hjemdahl |
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| Institution: | 1. Ecole Polytechnique, Laboratoire d''Informatique, Palaiseau, France;2. Biologie et Thérapies Innovantes des Cancers Localement Agressifs (BioTICLA) EA 4656, F-14032 Caen, France;3. Normandie Univ France, France;4. Centre François-Baclesse, Caen, France;2. Center for Medical Technology Policy, Baltimore, Maryland;3. Novartis Pharma AG, Basel, Switzerland;4. Allergy and Asthma Network, Vienna, Virginia;6. Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York;5. Pulmonary and Critical Care Medicine, Washington University, St. Louis, Missouri;2. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN;3. Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC;4. Departments of Surgery, UT Southwestern Medical Center, Dallas, TX;1. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA |
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| Abstract: | Catecholamine (CA) determinations are valuable tools in studies of sympatho-adrenal activity. However, several methodological problems should be considered when designing experiments and interpreting plasma CA results. The commonly assessed antecubital venous noradrenaline (NA) concentrations reflect local nerve activity, since about half of this NA is derived from the forearm tissues. Sympathetic nerve activity is not uniform, but may vary considerably between organs. Overall sympathetic activity is best assessed by measurements of NA in arterial or mixed venous blood. Venous adrenaline (ADR) levels may also be unrepresentative due to marked and variable extraction in the peripheral tissues. Urinary NA and ADR excretion studies still provide valuable information. Regional studies of NA overflow from individual organs give good estimates of local nerve activity and will increase the understanding of the functional organization of the sympathetic nervous system. |
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