Spike propagation in dendrites with stochastic ion channels |
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Authors: | Kamran Diba Christof Koch Idan Segev |
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Institution: | (1) Division of Biology, 1200 E. California Blvd, Pasadena, CA, 91125;(2) Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Ave, Newark, NJ, 07102;(3) Life Sciences Institute and Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, 91904, Israel |
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Abstract: | We investigate the effects of the stochastic nature of ion channels on the faithfulness, precision and reproducibility of
electrical signal transmission in weakly active, dendritic membrane under in vitro conditions. The properties of forward and
backpropagating action potentials (BPAPs) in the dendritic tree of pyramidal cells are the subject of intense empirical work
and theoretical speculation (Larkum et al., 1999; Zhu, 2000; Larkum et al., 2001; Larkum and Zhu, 2002; Schaefer et al., 2003;
Williams, 2004; Waters et al., 2005). We numerically simulate the effects of stochastic ion channels on the forward and backward
propagation of dendritic spikes in Monte-Carlo simulations on a reconstructed layer 5 pyramidal neuron. We report that in
most instances there is little variation in timing or amplitude for a single BPAP, while variable backpropagation can occur
for trains of action potentials. Additionally, we find that the generation and forward propagation of dendritic Ca2+ spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing
of Ca2+ spikes.
Action Editor : Alain Destexhe |
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Keywords: | temporal precision spike reliability coincidence detection |
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