Platelet-derived growth factor stimulates the phosphorylation of ribosomal protein S6 |
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Authors: | J Nishimura T F Deuel |
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Institution: | Departments of Medicine and Biological Chemistry, Washington University School of Medicine, The Jewish Hospital of St. Louis, St Louis, MO 63110, USA |
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Abstract: | The human platelet derived-growth factor (PDGF) is both a potent mitogen and a strong chemoattractant protein for cells involved in inflammation and repair. In seeking mechanisms by which PDGF might initiate specific activities in target cells, it was found that highly purified PDGF stimulates the phosphorylation of an Mr approximately 33000 protein in confluent Swiss mouse 3T3 cells Biochem. Biophys. Res. Commun. (1981) 103, 355-361]. The Mr approximately 33000 protein has now been recovered in polysomes by differential centrifugation and identified as ribosomal protein S6 by two-dimensional polyacrylamide gel electrophoresis. |
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Keywords: | Platelet-derived growth factor Protein phosphorylation S6 protein Ribosomal protein |
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