Nitrosomethylurea disturbs differentiation of mouse embryonic lungs in organ cultures |
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Authors: | N V Popova L Rossi |
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Institution: | (1) Institute of Carcinogenesis, Blokhin Oncological Science Center, Russian Academy of Medical Sciences, 115478 Moscow, Russia;(2) National Cancer Institute, Genoa, Italy |
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Abstract: | We have studied the effect of nitrosomethylurea (NMU) on the differentiation of early rudiments of mouse embryonic lungs (12th
day of embryogenesis) explanted into an organ culture. We have demonstrated that nontoxic doses of NMU are capable of accelerating
normal lung differentiation both at the early (increase in the number of epithelial buds) and at the late (increase in the
number of explants with regions of well-developed alveoli) stages of cultivation. However, NMU induces disturbances of differentiation,
which appear as polycystic structures and hyperplastic nodules generally absent in the control. |
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Keywords: | growth factors embryonic lungs organ cultures |
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