| 大鼠发育过程中下丘脑神经元钾离子通道温度效应变化的研究 |
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| 引用本文： | 蔡春青,邹飞.大鼠发育过程中下丘脑神经元钾离子通道温度效应变化的研究[J].生命科学研究,2006,10(1):24-27. |
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| 作者姓名： | 蔡春青 邹飞 |
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| 作者单位： | 南方医科大学,高温医学研究室,中国广东,广州,510515 |
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| 基金项目： | 国家自然科学基金资助项目(30371575)，广东省自然科学基金资助项目(32835) |
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| 摘 要： | 为了探讨出生后钾离子通道在下丘脑神经元热敏感分化过程中的作用,采用膜片钳技术研究出生一个月内SD大鼠急性分离神经元的温度效应,结果表明IK电流密度在出生后一个月内变化不大(P>0.05),而IA电流密度则呈现为升高趋势(P<0.05).同时升高温度,不同出生日期的钾通道NPo都有不同程度的升高,但相较P1d的神经元来说,温度对P18d的电压依赖性影响更大一些.同时温度对IK和IA的影响是不一样的,IA的Q10>2,所有这些显示IA通道在神经元温度敏感性的发育分化过程中起着重要的作用.
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| 关 键 词： | 下丘脑 发育 温度 钾通道 |
| 文章编号： | 1007-7847（2006）01-0024-04 |
| 收稿时间： | 2005-10-06 |
| 修稿时间： | 2005-12-28 |
Effect of Temperature on Potassium Currents in Rat Hypothalamic Neurons During Postnatal Development |
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| CAI Chun-qing,ZOU Fei.Effect of Temperature on Potassium Currents in Rat Hypothalamic Neurons During Postnatal Development[J].Life Science Research,2006,10(1):24-27. |
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| Authors: | CAI Chun-qing ZOU Fei |
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| Abstract: | The aim of the study was to investigate temperature effects on potassium currents,which influence the process of hypothalamic neurons development and differentiation.The experiments were carried out on the postnatal neurons using the patch-clamp technique.The results showed that the current density of IA increased(P<0.05) while IK had no significant changes during postnatal for 30 d.If raising temperature,NPo of single potassium currents of different birth date increased to some extent.Temperature effects on both IK and IA are different with Q10.>2 for IA.All these show that IA played an important role in the process of tempera-ture-sensitive development and differentiation. |
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| Keywords: | hypothalamus development temperature potassium channels |
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