Computational modeling and in silico analysis of differential regulation of myo-inositol catabolic enzymes in Cryptococcus neoformans |
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| Authors: | Emalee A Mackenzie Lisa S Klig |
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| Affiliation: | (1) Life Sciences Department, Irvine Valley College, Irvine, CA, USA;(2) Department of Biological Sciences, California State University, Long Beach, CA, USA |
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| Abstract: | Background Inositol is a key cellular metabolite for many organisms. Cryptococcus neoformans is an opportunistic pathogen which primarily infects the central nervous system, a region of high inositol concentration, of immunocompromised individuals. Through the use of myo-inositol oxygenase C. neoformans can catabolize inositol as a sole carbon source to support growth and viability. |
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