| Hedgehog信号通路与脂肪形成 |
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| 引用本文： | 王曦晨,史铭欣,李辉,王宁. Hedgehog信号通路与脂肪形成[J]. 细胞生物学杂志, 2011, 0(8) |
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| 作者姓名： | 王曦晨 史铭欣 李辉 王宁 |
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| 作者单位： | 东北农业大学动物科学与技术学院动物分子遗传学实验室; |
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| 基金项目： | 黑龙江省教育厅海外学人科研资助重点项目(No.1153h04); 973课题(No.2009CB941604); 教育部留学回国人员科研启动资金资助项目~~ |
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| 摘 要： | Hedgehog(Hh)信号通路是从果蝇到人类都非常保守的信号通路,在脊椎动物和非脊椎动物胚胎期多种组织器官的发育中发挥着重要作用。Hh信号通路的异常会导致疾病(先天性缺陷和癌症)的发生。近年的研究发现,Hh信号通路在脂肪生长发育中发挥重要作用,激活Hh信号通路能特异性地抑制白色脂肪组织细胞的分化,而对棕色脂肪组织细胞分化没有作用。该文综述了Hh信号通路在脂肪细胞分化中的作用及其分子机制,并对今后的研究和应用作了展望。
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| 关 键 词： | Hedgehog(Hh)信号通路 脂肪细胞 细胞分化 |
Hedgehog Signaling Pathway and Adipogensis |
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| Wang Xichen,Shi Mingxin,Li Hui,Wang Ning. Hedgehog Signaling Pathway and Adipogensis[J]. Chinese Journal of Cell Biology, 2011, 0(8) |
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| Authors: | Wang Xichen Shi Mingxin Li Hui Wang Ning |
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| Affiliation: | Wang Xichen,Shi Mingxin,Li Hui,Wang Ning~* (Laboratory of Animal Molecular Genetics,College of Animal Science and Technology,Northeast Agricultural University,Harbin 150030,China) |
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| Abstract: | Hedgehog(Hh) signaling pathway is a highly conserved pathway from Drosophila to Human, which plays a crucial role in embryonic development of many tissues both in invertebrates and vertebrates.The dysregulation of the pathway causes several pathologies,such as congenital defects and cancer.Recent studies have found that Hh signaling pathway plays an important role in the growth and development of adipose tissue, activation of Hh signaling inhibits white but not brown adipose cell differentiation.This review... |
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| Keywords: | Hedgehog signaling pathway adipocyte cell differentiation |
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