| 黏着斑激酶与肿瘤发生、发展及预后的关系 |
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| 引用本文： | 杨艳丽,李鹏鸽,葛玉婷,尹田乐,侯颖春. 黏着斑激酶与肿瘤发生、发展及预后的关系[J]. 细胞生物学杂志, 2011, 0(1) |
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| 作者姓名： | 杨艳丽 李鹏鸽 葛玉婷 尹田乐 侯颖春 |
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| 作者单位： | 陕西师范大学生命科学学院; |
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| 基金项目： | 陕西省自然科学基础研究计划项目基金(No.SJ08-ZT09)资助项目~~ |
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| 摘 要： | 黏着斑激酶(focal adhesion kinase,FAK)作为一种非受体蛋白酪氨酸激酶,因其与肿瘤间的密切联系而备受关注。多年研究发现,FAK在许多肿瘤中过表达,通过多条信号通路调控细胞侵袭、迁移、增殖及凋亡等,从而参与肿瘤的发生、发展进程。研究表明FAK可以作为肿瘤预后因子,是潜在的抗肿瘤治疗靶点。本文对FAK与肿瘤进程的关系作一综述,以期更好地认识FAK在肿瘤发生、发展过程中所起的作用,为相关研究者提供资料参考。
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| 关 键 词： | 黏着斑激酶 肿瘤发生 肿瘤发展 肿瘤预后 |
Focal Adhesion Kinase:Implications with Oncogenesis,Tumor Development and Prognosis |
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| Yan-Li Yang,Peng-Ge Li,Yu-Ting Ge,Tian-Le Yin,Ying-Chun Hou. Focal Adhesion Kinase:Implications with Oncogenesis,Tumor Development and Prognosis[J]. Chinese Journal of Cell Biology, 2011, 0(1) |
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| Authors: | Yan-Li Yang Peng-Ge Li Yu-Ting Ge Tian-Le Yin Ying-Chun Hou |
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| Affiliation: | Yan-Li Yang,Peng-Ge Li,Yu-Ting Ge,Tian-Le Yin,Ying-Chun Hou~* (College of Life Science,Shaanxi Normal University,Xi'an 710062,China) |
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| Abstract: | It is reported that focal adhesion kinase(FAK) is excessively expressed in many tumors,which is associated with cell invasion,proliferation,cell motility,apoptosis,oncogenesis,and tumor development.It is also reported that FAK may act as a prognosis factor for tumor development,and serve as a potential new target for cancer therapy.In this paper,the advances described as above are reviewed and summarized,and the feasibility of FAK as a tumor marker for tumor diagnosis and prognosis was estimated. |
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| Keywords: | FAK oncogenesis tumor development tumor prognosis |
| 本文献已被 CNKI 等数据库收录！ |
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