Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates |
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| Authors: | Karl R Wotton Frida K Weierud Susanne Dietrich Katharine E Lewis |
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| Institution: | (1) Department of Craniofacial Development, King's College London, Floor 27 Guy's Tower, Guy's Hospital, London Bridge, London, SE1 9RT, UK;(2) Physiology Development & Neuroscience Department, Cambridge University, Anatomy Building, Downing Street, Cambridge, CB2 3DY, UK |
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| Abstract: | Background
Lbx/ladybird genes originated as part of the metazoan cluster of Nk homeobox genes. In all animals investigated so far, both the protostome genes and the vertebrate Lbx1 genes were found to play crucial roles in neural and muscle development. Recently however, additional Lbx genes with divergent expression patterns were discovered in amniotes. Early in the evolution of vertebrates, two rounds of
whole genome duplication are thought to have occurred, during which 4 Lbx genes were generated. Which of these genes were maintained in extant vertebrates, and how these genes and their functions
evolved, is not known. |
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