| 真核细胞伴侣素CCT及其与细胞骨架的关系 |
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| 引用本文： | 段芳蕾,孙兴旺,曹灵. 真核细胞伴侣素CCT及其与细胞骨架的关系[J]. 细胞生物学杂志, 2011, 0(7) |
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| 作者姓名： | 段芳蕾 孙兴旺 曹灵 |
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| 作者单位： | 泸州医学院病理学教研室;泸州医学院附属医院肾病内科; |
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| 基金项目： | 四川省教育厅重点项目(No.2006A049); 泸州市科技局项目(No.2007(64)-2)资助项目~~ |
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| 摘 要： | CCT(the chaperonin containing tailless complex polypeptide 1)是一种广泛存在于细胞浆中的异型寡聚蛋白,也是迄今为止真核细胞胞浆中发现的唯一伴侣素。目前认为大约15%的哺乳动物蛋白折叠需要CCT的参与,其中研究得最多的是肌动蛋白和微管蛋白。研究发现,CCT的异常会导致细胞骨架蛋白发生改变,甚至影响细胞骨架的形成与解聚。由此推测,一些细胞骨架相关疾病可能与CCT异常有关。
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| 关 键 词： | 伴侣素 CCT 细胞骨架 肌动蛋白 微管蛋白 |
The Chaperonin Containing Tailless Complex Polypeptide 1(CCT) and Its Relationship with the Cytoskeleton |
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| Duan Fanglei,Sun Xingwang,Cao Ling. The Chaperonin Containing Tailless Complex Polypeptide 1(CCT) and Its Relationship with the Cytoskeleton[J]. Chinese Journal of Cell Biology, 2011, 0(7) |
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| Authors: | Duan Fanglei Sun Xingwang Cao Ling |
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| Affiliation: | Duan Fanglei~1,Sun Xingwang~(1*),Cao Ling~2 (1 Department of Pathology,Luzhou Medical College,Luzhou 646000,China,2 Department of Nephrology,Luzhou Medical College Affiliated Hospital,China) |
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| Abstract: | CCT(the chaperonin containing tailless complex polypeptide 1) is a hetero-oligomeric protein widely existing in the cytoplasm,and is also the only chaperonin so far found in eukaryotic cytoplasm.In present opinion,about 15 percent of mammalian proteins folding need CCT participation.The most studied CCT substrates are actin and tubulin.It was found that abnormal CCT would lead to the changes of cytoskeletal proteins,and even affect the formation and depolymerization of cytoskeleton.It is inferred that a num... |
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| Keywords: | chaperonin CCT cytoskeleton actin tublin |
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