Role of Dopaminergic Neurons in Denervation-Induced α1-Adrenergic Up-Regulation in the Rat Cerebral Cortex |
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Authors: | Gabriel Nowak Joanna Zak Jerzy Superata |
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Institution: | Institute of Pharmacology, Polish Academy of Sciences, Krakow. |
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Abstract: | The density of 3H]prazosin binding to alpha 1-adrenoceptors in the rat cortex was measured after selective and mixed noradrenergic or dopaminergic lesions. DSP-4 produced a selective noradrenergic lesion and increased the density of alpha 1-adrenoceptors. 6-Hydroxydopamine produced a selective dopaminergic lesion (after desipramine protection of noradrenergic neurons) and a mixed noradrenergic and dopaminergic lesion that did not change the cortical alpha 1-adrenoceptor binding. On the basis of the results obtained, a hypothesis is put forward that the central dopaminergic system controls the denervation-induced cortical alpha 1-adrenoceptor up-regulation. |
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Keywords: | Rat cortex Noradrenergic lesion Dopaminergic lesion α1-Adrenoceptors |
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