A robust two-way semi-linear model for normalization of cDNA microarray data期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A robust two-way semi-linear model for normalization of cDNA microarray data

Authors:	Deli?Wang author-information" > author-information__contact u-icon-before" > mailto:deli.wang@ccc.uab.edu" title=" deli.wang@ccc.uab.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Jian?Huang author-information" > author-information__contact u-icon-before" > mailto:jian@stat.uiowa.edu" title=" jian@stat.uiowa.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Hehuang?Xie,Liliana?Manzella,Marcelo?Bento?Soares

Affiliation:	(1) Biostatistics and Bioinformatics Unit, Comprehensive Cancer Center, the University of Alabama at Birmingham, Birmingham, AL 35294, USA;(2) Department of Statistics and Actuarial Science, and Program in Public Health Genetics, the University of Iowa, Iowa City, IA 52242, USA;(3) Department of Pediatrics, the University of Iowa, Iowa City, IA 52242, USA;(4) Departments of Biochemistry, Orthopaedics, Physiology and Biophysics, the University of Iowa, Iowa City, IA 52242, USA

Abstract:	Background Normalization is a basic step in microarray data analysis. A proper normalization procedure ensures that the intensity ratios provide meaningful measures of relative expression values.

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