A robust two-way semi-linear model for normalization of cDNA microarray data期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A robust two-way semi-linear model for normalization of cDNA microarray data

Authors:	Email author" target="_blank">Deli?Wang Email author Email author" target="_blank">Jian?Huang Email author Hehuang?Xie Liliana?Manzella Marcelo?Bento?Soares

Institution:	(1) Biostatistics and Bioinformatics Unit, Comprehensive Cancer Center, the University of Alabama at Birmingham, Birmingham, AL 35294, USA;(2) Department of Statistics and Actuarial Science, and Program in Public Health Genetics, the University of Iowa, Iowa City, IA 52242, USA;(3) Department of Pediatrics, the University of Iowa, Iowa City, IA 52242, USA;(4) Departments of Biochemistry, Orthopaedics, Physiology and Biophysics, the University of Iowa, Iowa City, IA 52242, USA

Abstract:	Background Normalization is a basic step in microarray data analysis. A proper normalization procedure ensures that the intensity ratios provide meaningful measures of relative expression values.

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