Site-specific and synergistic stimulation of methylation on the bacterial chemotaxis receptor Tsr by serine and CheW |
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Authors: | Anas?Chalah Email author" target="_blank">Robert?M?WeisEmail author |
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Institution: | (1) Department of Chemistry, University of Massachusetts, 710 North Pleasant St., 01003-9336 Amherst, MA, USA |
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Abstract: | Background Specific glutamates in the methyl-accepting chemotaxis proteins (MCPs) of Escherichia coli are modified during sensory adaptation. Attractants that bind to MCPs are known to increase the rate of receptor modification,
as with serine and the serine receptor (Tsr), which contributes to an increase in the steady-state (adapted) methylation level.
However, MCPs form ternary complexes with two cytoplasmic signaling proteins, the kinase (CheA) and an adaptor protein (CheW),
but their influences on receptor methylation are unknown. Here, the influence of CheW on the rate of Tsr methylation has been
studied to identify contributions to the process of adaptation. |
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Keywords: | |
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