The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment |
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Authors: | Email author" target="_blank">Mohamed?FM?MitwallyEmail author Robert?F?Casper Michael?P?Diamond |
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Institution: | (1) Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Wayne State University, Detroit, Michigan, USA;(2) Reproductive Sciences Division, Department of Obstetrics & Gynecology, University of Toronto, Toronto, Ontario, Canada |
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Abstract: | Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable
therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial
receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation
has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors
reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors
during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing
hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is
an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of
the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality. |
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