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Differential range and activity of various forms of the Hedgehog protein |
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| Authors: | Rebecca?J?Dawber Stephen?Hebbes Bram?Herpers France?Docquier |
| Institution: | (1) MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK;(2) Cell and Molecular Biosciences, University of Newcastle, Newcastle-upon-Tyne, UK;(3) Cell Biology, UMC Utrecht, Utrecht, The Netherlands;(4) Department of Biological Sciences, University of Essex, Colchester, UK |
| Abstract: | BackgroundThe Hedgehog (Hh) family of secreted proteins act as extra cellular messengers to control and coordinate growth and differentiation. The mechanism by which Hh protein travels across a field of cells, and results in a range of specific effects relating to the distance from the source, has been the subject of much debate. It has been suggested that the range and activity of the pathway can be linked to modifications of the Hh protein, specifically the addition of lipid groups at N- and C-terminal sites. |
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