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NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
Affiliation:1. Department of Neuroscience, Washington University School of Medicine, St Louis, MO 63110-1093, USA;1. Department of Integrative Structural and Computational Biology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA;2. Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA;3. HHMI Faculty Scholar, Chevy Chase, MD 20815, USA;1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China;4. School of Medicine, Sun Yat-sen University, Shenzhen 518107, China;5. Ministry of Education (MOE) Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China;6. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China;1. Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA;2. Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 21224, USA;3. Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY 10461, USA;4. Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA;5. JHU SOM Microscope Facility, Johns Hopkins University, Baltimore, MD 21205, USA;6. Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA;7. Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD 21229, USA;8. Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA;1. Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;2. Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;3. EpiQMAx GmbH, Planegg, Germany;4. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK;5. Technische Universität Berlin, Chair of Bioanalytics, Berlin, Germany;6. Faculty of Medicine, Biomedical Center, Protein Analysis Unit, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany;1. T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA;2. Chemical Biology Interface Program, Johns Hopkins University, Baltimore, MD 21218, USA;1. Shanxi Provincial Key Laboratory of Protein Structure Determination, Shanxi Academy of Advanced Research and Innovation, Taiyuan 030012, China;2. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;3. Cryo-EM Center, Southern University of Science and Technology, Shenzhen 518055, China;4. College of Life Sciences, Shanxi Agricultural University, Taiyuan 030031, China;5. Shanxi Provincial Key Laboratory for Major Infectious Disease Response, Taiyuan 030012, China;6. The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China;7. National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;8. Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;9. College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China;10. Beijing Life Science Academy, Beijing 102209, China
Abstract:
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  • Keywords:DNA methylation  neurodevelopmental disease  non-CG methylation  Sotos syndrome  histone methylation  DNMT3A  NSD1  genome topology
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