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Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells
Affiliation:1. Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain;4. CNAG-CRG, Baldiri Reixac 4, Barcelona 08028, Spain;5. Blanquerna School of Health Science, Universitat Ramon Llull, Barcelona 08025, Spain;1. Division of Neonatology, Department of Pediatrics, Duke University Medical Center, The Jean and George Brumley, Jr. Neonatal-Perinatal Institute, Durham, NC 27710, USA;2. Duke Proteomics and Metabolomics Shared Resource, Center for Genomics and Computational Biology, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA;3. Department of Pharmacology and Cancer Biology, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA;4. Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA;5. Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA;6. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA;7. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA;8. Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA;9. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA;1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China;4. School of Medicine, Sun Yat-sen University, Shenzhen 518107, China;5. Ministry of Education (MOE) Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China;6. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China;1. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Department of Hepatopancreatobiliary Surgery, Shenzhen Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, China;3. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;1. Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK;2. Kavli Institute for Nanoscience Discovery, Oxford OX1 3QU, UK;3. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK;4. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK;5. OMass Therapeutics, Ltd., Oxford OX4 2GX, UK;1. DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK;2. DNA Recombination and Repair Laboratory, The Francis Crick Institute, London NW1 1AT, UK;3. Section of Structural Biology, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK;4. Department of Infectious Disease, Faculty of Medicine, Imperial College London, London W12 0NN, UK;5. Single Molecule Imaging Group, MRC-London Institute of Medical Sciences, London W12 0NN, UK;6. Single Molecule Imaging of Genome Duplication and Maintenance Laboratory, The Francis Crick Institute, London NW1 1AT, UK;1. Laboratory of Cellular and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA;2. Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA;3. National Institute of General Medical Sciences, NIH, Bethesda, MD 20892, USA
Abstract:
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Keywords:gene regulation  cell cycle  stem cells  cell fate  Thymine DNA glycosylase  p53  pluripotency  cardiomyocyte  self-renewal  proteomics
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