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The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining
Affiliation:1. Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO, USA;2. Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, TX, USA;3. DSB Repair Metabolism Laboratory, The Francis Crick Institute, London, UK;4. Artios Pharma Ltd, Babraham Research Campus, Cambridge CB22 3FH, UK;1. Research Group of Proteomics and ADP-Ribosylation Signaling, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany;2. Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA;3. Univ Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes) – UMR 6290, BIOSIT (Biologie, Santé, Innovation Technologique de Rennes) – UMS 3480, US 018, 35000 Rennes, France;4. Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, Biological Research Centre, Eötvös Loránd Research Network (ELKH), 6276 Szeged, Hungary;5. Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, 6276 Szeged, Hungary;6. Department of Immunology, Albert Szent-Györgyi Medical School, Faculty of Science and Informatics, University of Szeged, 6720 Szeged, Hungary;7. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;8. Institut Universitaire de France, Paris, France;9. Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany;1. Department of Hematology/Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;1. Genome Stability Unit, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia;2. Department of Medicine (St Vincent’s Health), University of Melbourne, Fitzroy, VIC 3065, Australia;3. The Institute of Cancer Research, London SW3 6JB, UK;4. Molecular Genetics Unit, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia;1. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;2. Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892-4254, USA;1. Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA;2. Department of Breast Surgery, Guizhou Provincial People’s Hospital, Guiyang, Guizhou 550002, China;3. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA;4. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA;5. Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA;1. Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA;2. Division of Genetics, Brigham and Women’s Hospital, Boston, MA 02115, USA;3. Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
Abstract:
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  • Keywords:DNA repair  MMEJ  cancer  APE2  APEX2  synthetic lethality  PARP  Homologous Recombination  HR-deficient
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