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Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
Affiliation:1. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA;2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;3. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;4. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA;5. Howard Hughes Medical Institute, Boston, MA 02115, USA;6. Department of Microbiology, New York University, Grossman School of Medicine, New York, NY 10016, USA;7. Morrisey School of Arts and Science, Boston College, Boston, MA 02467, USA;8. Division of Rheumatology, Inflammation, and Immunity, Brigham and Women''s Hospital, Boston, MA 02115, USA
Abstract:
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  • Keywords:innate immunity  integrated stress response  RIG-I-like receptor  antiviral signaling  stress granule  dsRNA  molecular condensate  ADAR1  immune-mediated apoptosis  immunopathology
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