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Evolutionary origins and interactomes of human,young microproteins and small peptides translated from short open reading frames
Affiliation:1. Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany;2. DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany;3. Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Core Facility Proteomics, 10117 Berlin, Germany;4. Charité-Universitätsmedizin, 10117 Berlin, Germany;5. Institute for Systems Biology, Seattle, WA 98109, USA;6. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK;7. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;8. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;9. Division of Pediatric Hematology/Oncology, Boston Children’s Hospital, Boston, MA 02115, USA;10. Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark;11. Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands
Abstract:
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  • Keywords:short ORFs  microproteins  short peptides  ribosome profiling  protein evolution  primate-specific proteins  protein interactome  PRISMA  short linear motifs, SLiMs
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