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U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes
Institution:1. Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA;2. Ludwig Center at Harvard, Boston, MA 02115, USA;3. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;1. Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA;2. Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA;3. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA;4. Department of Medicine, Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA;5. Department of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY 14642, USA;6. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;7. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA;1. Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA;1. Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA;2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;3. Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA;4. The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA;5. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA;6. Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA;1. Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany;2. Max Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry Group, Am Fassberg 11, 37077 Göttingen, Germany;3. University Medical Center Göttingen, Institute of Clinical Chemistry, Bionalytics Group, Robert-Koch-Straße 40, 37075 Göttingen, Germany;1. Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA;2. Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA;3. Department of Physics, The Ohio State University, Columbus, OH 43210, USA;4. Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA;5. Department of Physics, The Pennsylvania State University, University Park, PA 16802, USA;6. Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH 43210, USA;1. Departments of Medicine, Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
Abstract:
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