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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
Affiliation:1. Signalling Programme, Babraham Institute, Cambridge CB22 3AT, UK;2. Department of Structural and Functional Biology, São Paulo State University, Botucatu, SP CEP: 18618-689, Brazil;3. European Cancer Stem Cell Research Institute, Cardiff University, Cardiff CF24 4HQ, UK;4. Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia;5. Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;6. Mass Spectrometry Facility, Babraham Institute, Cambridge CB22 3AT, UK;7. Gene Targeting Facility, Babraham Institute, Cambridge CB22 3AT, UK;8. Bioinformatics, Babraham Institute, Cambridge CB22 3AT, UK;9. Imaging Facility, Babraham Institute, Cambridge CB22 3AT, UK;10. Projects Group, Oncology R&D, AstraZeneca, Cambridge, UK
Abstract:
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  • Keywords:PLEKHS1  PI3K  PTEN  IRS1  Src-family kinase  prostate
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