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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
Affiliation:1. Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA;2. Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China;3. Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA;4. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA;5. Jinzhou Medical University, Shanghai East Hospital, Shanghai 200120, China;6. Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN 55905, USA;7. Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200092, China;1. Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA;1. State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China;2. Peking University Institute of Advanced Agricultural Sciences, Weifang, Shandong 261325, China;3. Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences (CAS), Shanghai 201602, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;1. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;2. Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892-4254, USA;1. Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany;2. Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany;3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, USA;5. Howard Hughes Medical Institute;1. CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China;2. Department of Clinical Laboratory, Linyi People''s Hospital, Xuzhou Medical University, Shandong 276000, China;3. Shanghai Jiao Tong University Affiliated Sixth People''s Hospital, Shanghai 200233, China;4. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China;1. Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA;2. Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), 8093 Zürich, Switzerland;3. Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, 6500 Bellinzona, Switzerland;4. Department of Genetics & Development, Columbia University Irving Medical Center, New York, NY 10032, USA
Abstract:
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  • Keywords:non-homologous end joining  chromatin topology  chromatin mobility  53BP1  SLFN5  telomere fusions  class switch recombination  PARP inhibitor sensitivity  DNA double-strand break repair  super-resolution microscopy
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