Acinar cells and the development of pancreatic fibrosis |
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| Affiliation: | 1. SCUT-QMPH Joint Laboratory for Pancreatic Cancer Research, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People''s Hospital, Qingyuan, Guangdong 511518, China;2. Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, Guangdong 510006, China;1. Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, 515063, China;2. Institute of Marine Sciences, Shantou University, Shantou, 515063, China;3. Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Fisheries College, Jimei University, Xiamen, 361021, China;1. Key Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing, 100048, China;2. Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou, 521000, China;3. Shanxi Xinghuacun Fenjiu Distillery Co., Ltd., Fenyang, Shanxi, 032205, China;4. School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China;1. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200–135 Porto, Portugal;2. Cancer Drug Resistance Group, IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Portugal, 4200–135 Porto, Portugal;3. Department of Biological Sciences, FFUP - Faculty of Pharmacy of the University of Porto, Porto, Portugal;4. Department of Oncology, University of Torino, 10126 Torino, Italy;5. Interdepartmental Research Center for Molecular Biotechnology “G. Tarone”, University of Torino, 10126 Torino, Italy;1. School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China;2. Pan Asia (Jiangmen) Institute of Biological Engineering and Health, Jiangmen 529080, China;3. Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Guangzhou 510006, China;1. Guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals, Guangdong Province Famous Fish Reproduction and Breeding Engineering Technology Research Center, Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China;2. Key Laboratory of Utilization and Conservation for Tropical Marine Bioresources of Ministry of Education, Hainan Key Laboratory for Conservation and Utilization of Tropical Marine Fishery Resources, Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya 572022, China;3. Hainan Chenhai Aquatic co., LTD, Sanya 572022, China;1. Department of Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China;2. Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China;3. Department of Neurobiology, Harbin Medical University, Harbin 150081, China |
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| Abstract: | Pancreatic fibrosis is caused by excessive deposition of extracellular matrixes of collagen and fibronectin in the pancreatic tissue as a result of repeated injury often seen in patients with chronic pancreatic diseases. The most common causative conditions include inborn errors of metabolism, chemical toxicity and autoimmune disorders. Its pathophysiology is highly complex, including acinar cell injury, acinar stress response, duct dysfunction, pancreatic stellate cell activation, and persistent inflammatory response. However, the specific mechanism remains to be fully clarified. Although the current therapeutic strategies targeting pancreatic stellate cells show good efficacy in cell culture and animal models, they are not satisfactory in the clinic. Without effective intervention, pancreatic fibrosis can promote the transformation from pancreatitis to pancreatic cancer, one of the most lethal malignancies. In the normal pancreas, the acinar component accounts for 82% of the exocrine tissue. Abnormal acinar cells may activate pancreatic stellate cells directly as cellular source of fibrosis or indirectly via releasing various substances and initiate pancreatic fibrosis. A comprehensive understanding of the role of acinar cells in pancreatic fibrosis is critical for designing effective intervention strategies. In this review, we focus on the role of and mechanisms underlying pancreatic acinar injury in pancreatic fibrosis and their potential clinical significance. |
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| Keywords: | Pancreas Fibrosis Inflammation Oncogenesis Acinar cells |
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