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The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field |
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| Authors: | Fadee G Mondalek Yuan Yuan Zhang Bradley Kropp Richard D Kopke Xianxi Ge Ronald L Jackson Kenneth J Dormer |
| Institution: | (1) Department of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA;(2) Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;(3) Hough Ear Institute, Oklahoma City, OK, USA;(4) Naval Medical Center, San Diego, CA, USA;(5) Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| Abstract: | BackgroundSensorineural hearing loss, a subset of all clinical hearing loss, may be correctable through the use of gene therapy. We are testing a delivery system of therapeutics through a 3 cell-layer round window membrane model (RWM model) that may provide an entry of drugs or genes to the inner ear. We designed an in vitro RWM model similar to the RWM (will be referred to throughout the paper as RWM model) to determine the feasibility of using superparamagnetic iron oxide (Fe3O4) nanoparticles (SPION) for targeted delivery of therapeutics to the inner ear. |
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