Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples |
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| Authors: | Jaroslav P Novak Merrill C Miller III Douglas A Bell |
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| Affiliation: | (1) McGill University and Genome Quebec Innovation Centre, 740 Dr. Penfield, Montreal, Quebec, H3A 1A4, Canada;(2) Environmental Genomics Section, Laboratory of Molecular Genetics, C3-03, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA |
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| Abstract: | Background Gene expression microarray technology continues to evolve and its use has expanded into all areas of biology. However, the high dimensionality of the data makes analysis a difficult challenge. Evaluating measurements and estimating the significance of the observed differences among samples remain important issues that must be addressed for each technology platform. In this work we use a consecutive sampling method to characterize the dispersion patterns of data generated from Illumina fiberoptic bead-based oligonucleotide arrays. |
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