|
|||||
|
|
Global similarity and local divergence in human and mouse gene co-expression networks |
|
| Authors: | Panayiotis Tsaparas Leonardo Mari?o-Ramírez Olivier Bodenreider Eugene V Koonin and I King Jordan |
| Institution: | (1) Basic Research Unit, Helsinki Institute for Information Technology, University of Helsinki, Helsinki, Finland;(2) National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA;(3) National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA;(4) Present address: School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA |
| Abstract: | BackgroundA genome-wide comparative analysis of human and mouse gene expression patterns was performed in order to evaluate the evolutionary divergence of mammalian gene expression. Tissue-specific expression profiles were analyzed for 9,105 human-mouse orthologous gene pairs across 28 tissues. Expression profiles were resolved into species-specific coexpression networks, and the topological properties of the networks were compared between species. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |