Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice |
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Authors: | Jin Xu Mingming Xu Ying-Xian Pan |
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Affiliation: | (1) Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA |
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Abstract: | Background The complexity of the mouse mu opioid receptor (Oprm) gene was demonstrated by the identification of multiple alternatively spliced variants and promoters. Our previous studies have identified a novel promoter, exon 11 (E11) promoter, in the mouse Oprm gene. The E11 promoter is located ~10 kb upstream of the exon 1 (E1) promoter. The E11 promoter controls the expression of nine splice variants in the mouse Oprm gene. Distinguished from the TATA-less E1 promoter, the E11 promoter resembles a typical TATA-containing eukaryote class II promoter. The aim of this study is to further characterize the E11 and E1 promoters in vivo using a transgenic mouse model. |
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