An extended window of opportunity for G-CSF treatment in cerebral ischemia |
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Authors: | Armin Schneider Rainer Wysocki Claudia Pitzer Carola Krüger Rico Laage Stefan Schwab Alfred Bach Wolf-Rüdiger Schäbitz |
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Institution: | 1. Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120, Heidelberg, Germany 2. Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, 48149, Münster, Germany 3. Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany 4. Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
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Abstract: | Background Granulocyte-colony stimulating factor (G-CSF) is known as a powerful regulator of white blood cell proliferation and differentiation
in mammals. We, and others, have shown that G-CSF is effective in treating cerebral ischemia in rodents, both relating to
infarct size as well as functional recovery. G-CSF and its receptor are expressed by neurons, and G-CSF regulates apoptosis
and neurogenesis, providing a rational basis for its beneficial short- and long-term actions in ischemia. In addition, G-CSF
may contribute to re-endothelialisation and arteriogenesis in the vasculature of the ischemic penumbra. In addition to these
trophic effects, G-CSF is a potent neuroprotective factor reliably reducing infarct size in different stroke models. |
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