Mast cells dysregulate apoptotic and cell cycle genes in mucosal squamous cell carcinoma |
| |
| Authors: | Sydney Ch'ng Michael Sullivan Lan Yuan Paul Davis Swee T Tan |
| |
| Affiliation: | (1) From the Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Wellington, New Zealand;(2) The Department of Medicine, Wellington School of Medicine & Health Sciences, Wellington, New Zealand;(3) The Children's Cancer Research Group, Christchurch School of Medicine & Health Sciences, Christchurch, New Zealand |
| |
| Abstract: | Background Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes to the biological behavior of the tumor are unclear. In vivo studies have demonstrated sequential mast cell infiltration and degranulation during squamous cell carcinogenesis. The degree of mast cell activation correlates closely with distinct phases of hyperkeratosis, dysplasia, carcinoma in-situ and invasive carcinoma. However, the role of mast cells in carcinogenesis is unclear. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
