Using the nucleotide substitution rate matrix to detect horizontal gene transfer |
| |
| Authors: | Micah Hamady M D Betterton Rob Knight |
| |
| Institution: | (1) Department of Computer Science, University of Colorado, Boulder, CO 80309, USA;(2) Department of Physics, 390 UCB, University of Colorado, Boulder, CO 80309, USA;(3) Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA |
| |
| Abstract: | Background Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many
medically important functions, such as conferring antibiotic resistance, improved detection of horizontally transferred genes
from sequence data would be an important advance. Existing sequence-based methods for detecting HGT focus on changes in nucleotide
composition or on differences between gene and genome phylogenies; these methods have high error rates. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
