The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene |
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Authors: | Veiko Krauss Anne Fassl Petra Fiebig Ina Patties Heinz Sass |
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Affiliation: | (1) Department of Genetics, Institute of Biology II, University of Leipzig, Johannisallee 21–23, 04103 Leipzig, Germany |
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Abstract: | Background In eukaryotes, histone H3 lysine 9 (H3K9) methylation is a common mechanism involved in gene silencing and the establishment of heterochromatin. The loci of the major heterochromatic H3K9 methyltransferase Su(var)3-9 and the functionally unrelated γ subunit of the translation initiation factor eIF2 are fused in Drosophila melanogaster. Here we examined the phylogenetic distribution of this unusual gene fusion and the molecular evolution of the H3K9 HMTase Su(var)3-9. |
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