The accuracy of several multiple sequence alignment programs for proteins |
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| Authors: | Paulo AS Nuin Zhouzhi Wang Elisabeth RM Tillier |
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| Affiliation: | (1) Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, 101 College St, M5G 1L7 Toronto, Ontario, Canada;(2) Dept. Medical Biophysics, University of Toronto, Toronto, Ontario, Canada |
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| Abstract: | Background There have been many algorithms and software programs implemented for the inference of multiple sequence alignments of protein and DNA sequences. The "true" alignment is usually unknown due to the incomplete knowledge of the evolutionary history of the sequences, making it difficult to gauge the relative accuracy of the programs. |
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