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Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer |
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| Authors: | Lucia Taja-Chayeb Alma Chavez-Blanco Jorge Martínez-Tlahuel Aurora González-Fierro Myrna Candelaria Jose Chanona-Vilchis Elizabeth Robles Alfonso Dueñas-Gonzalez |
| Affiliation: | 1. Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología/Instituto de Investigaciones Biomédicas,UNAM, Mexico 2. Division of Clinical Research, Instituto Nacional de Cancerología, Mexico 3. Department of Pathology, Instituto Nacional de Cancerología, Mexico |
| Abstract: | BackgroundDespite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived growth factor (PDGF) might have a role in the development of cervical cancer, therefore it is important to determine whether this growth factor pathway is functional and its targeting with imatinib mesylate leads to growth inhibition of cervical cancer cells. |
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