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Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals |
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| Authors: | Daniel Gendron Sandra Carriero Daniel Garneau Jonathan Villemaire Roscoe Klinck Sherif Abou Elela Masad J Damha Benoit Chabot |
| Affiliation: | 1. Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada 2. Department of chemistry, McGill University, Montréal, Québec, Canada |
| Abstract: | BackgroundWe previously described the use of tailed oligonucleotides as a means of reprogramming alternative pre-mRNA splicing in vitro and in vivo. The tailed oligonucleotides that were used interfere with splicing because they contain a portion complementary to sequences immediately upstream of the target 5' splice site combined with a non-hybridizing 5' tail carrying binding sites for the hnRNP A1/A2 proteins. |
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