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Low degree metabolites explain essential reactions and enhance modularity in biological networks |
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| Authors: | Areejit Samal Shalini Singh Varun Giri Sandeep Krishna Nandula Raghuram and Sanjay Jain |
| Institution: | (1) Department of Physics and Astrophysics, University of Delhi, Delhi, 110007, India;(2) National Centre for Biological Sciences, UAS-GKVK Campus, Bangalore, 560065, India;(3) School of Biotechnology, GGS Indraprastha University, Delhi, 110006, India;(4) Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, 560064, India;(5) Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA;(6) Physics and Geophysics, Niels Bohr Institute for Astronomy, Blegdamsvej 17, Copenhagen, DK-2100, Denmark |
| Abstract: | BackgroundRecently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes and reactions that are essential for the organism. A goal of computational and systems biology is to go beyond identification towards an explanation of specific modules and essential genes and reactions in terms of specific structural or evolutionary constraints. |
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