Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells |
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| Authors: | Fiorenza Ianzini Alessandro Bertoldo Elizabeth A Kosmacek Stacia L Phillips Michael A Mackey |
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| Affiliation: | (1) Departments of Pathology, Radiation Oncology, and Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA;(2) Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA;(3) Departments of Biomedical Engineering and Pathology, University of Iowa, Iowa City, IA 52242, USA |
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| Abstract: | Background We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-dependent kinase is activated, and abrogation of the G2/M checkpoint control occurs resulting in mitotic catastrophe (MC). |
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