Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding proteins |
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| Authors: | Michael E Bradley and Steven A Benner |
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| Institution: | (1) Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611, USA;(2) Foundation for Applied Molecular Evolution, 1115 NW 14th Avenue, Gainesville, FL 32601, USA;(3) Division of Biological Sciences, Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60615, USA |
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| Abstract: | Background When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information,
such as folded protein structures, analyses of the combined data often lead to new hypotheses about molecular physiology.
This represents an excellent example of how bioinformatics can be used to guide experimental research. However, progress in
this direction has been slowed by the lack of a publicly available resource suitable for general use. |
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