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Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus) |
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| Authors: | Suresh Yenugu Vishnu Chintalgattu Christopher J Wingard Yashwanth Radhakrishnan Frank S French Susan H Hall |
| Institution: | (1) Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA;(2) Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA;(3) Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605014, India |
| Abstract: | Backgroundbeta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract and have roles in non-immunological processes such as sperm maturation and capacitation. Characterization of novel defensins in the male reproductive tract can lead to increased understanding of their dual roles in immunity and sperm maturation. |
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