The neurochemical basis of human cortical auditory processing: combining proton magnetic resonance spectroscopy and magnetoencephalography |
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| Authors: | Peter S?r?s Nikolaus Michael Melanie Tollk?tter and Bettina Pfleiderer |
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| Institution: | (1) Department of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;(2) Department of Psychiatry, University Hospital M?nster, M?nster, Germany;(3) Department of Clinical Radiology, University Hospital M?nster, M?nster, Germany |
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| Abstract: | Background A combination of magnetoencephalography and proton magnetic resonance spectroscopy was used to correlate the electrophysiology
of rapid auditory processing and the neurochemistry of the auditory cortex in 15 healthy adults. To assess rapid auditory
processing in the left auditory cortex, the amplitude and decrement of the N1m peak, the major component of the late auditory
evoked response, were measured during rapidly successive presentation of acoustic stimuli. We tested the hypothesis that:
(i) the amplitude of the N1m response and (ii) its decrement during rapid stimulation are associated with the cortical neurochemistry
as determined by proton magnetic resonance spectroscopy. |
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