In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes |
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| Authors: | Federica Bestoso Laura Ottaggio Andrea Armirotti Alessandro Balbi Gianluca Damonte Paolo Degan Mauro Mazzei Francesca Cavalli Bernardetta Ledda Mariangela Miele |
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| Affiliation: | (1) Laboratory of Plant and Pharmaceutical Biotechnology, Advanced Biotechnology Center (ABC), Largo R. Benzi, 10, 16132 Genova, Italy;(2) Department of Translational Oncology, National Cancer Research Institute, IST, Largo R. Benzi, 10, 16132 Genova, Italy;(3) DIMES: Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 7, 16132 Genova, Italy;(4) Department of Pharmaceutical Sciences, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy |
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| Abstract: | Background Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield. Many attempts have been made to produce Taxol by chemical synthesis, semi-synthesis and plant tissue cultures. However, to date, the availability of this compound is not sufficient to satisfy the commercial requirements. The aim of the present work was to produce suspension cell cultures from plants not belonging to Taxus genus and to verify whether they produced Taxol and taxanes. For this purpose different explants of hazel (Corylus avellana species) were used to optimize the protocol for inducing in vitro callus, an undifferentiated tissue from which suspension cell cultures were established. |
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