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Evolutionary constraints on yeast protein size
Authors:Jonas Warringer  Anders Blomberg
Institution:(1) Department of Cell and Molecular Biology, Lundberg Laboratory, Gteborg University Medicinaregatan 9c, 41390 Gteborg, Sweden
Abstract:

Background  

Despite a strong evolutionary pressure to reduce genome size, proteins vary in length over a surprisingly wide range also in very compact genomes. Here we investigated the evolutionary forces that act on protein size in the yeast Saccharomyces cerevisiae utilizing a system-wide bioinformatics approach. Data on yeast protein size was compared to global experimental data on protein expression, phenotypic pleiotropy, protein-protein interactions, protein evolutionary rate and biochemical classification.
Keywords:
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